Spine and Spinal Disorders

Clinical Trials and Case Reports in Spine and Spinal Disorders

Spinal cord injury (SCI) has been investigated a hopeless condition and it often causes disastrous sequelae resulting from trauma (e.g. a car crash) or from disease. Reducing secondary damage is the key to its treatment. Distinct investigations and clinical trials have been implemented and some of them showed auspicious results; however, there is still no gold standard treatment with sufficient evidence. There is no predictable estimation of global popularity, but predicted annual global incidence is 40 to 80 cases per million populations. Up to 90% of these cases are due to traumatic causes. Around 250 000 and 500 000 people suffer with spinal cord injury (SCI) every year. People with SCI more likely to die prematurely than the people without a SCI, with worse survival rates in low-income and middle-income countries. The immediate side effect for the dominant part of spinal issue is persecution. Spine is very mind-boggling structure with various capacities. Ordinary maturing process prompts changes in vertebrae, tendons and intervertebral circles.Case reports, on the other hand, offer detailed descriptions of individual patient cases, highlighting unique presentations, diagnostic challenges, treatment approaches, and outcomes. While they lack the statistical power of clinical trials, case reports provide valuable insights into rare or unusual manifestations of spinal disorders, unexpected treatment responses, adverse events, and lessons learned in clinical practice. They offer clinicians an opportunity to learn from real-world experiences and expand their knowledge base, potentially influencing future research directions and clinical decision-making.